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    Home > Vegan Casserole Recipes

    Vegan Muffaletta Casserole

    Posted: Feb 26, 2022 ยท Updated: Mar 25, 2022

    Jump to Recipe Pin Recipe
    Front shot of a sandwich with text overlay that reads "vegan muffaletta casserole, new orleans style, vibrant flavors"

    Serve up this scrumptious Vegan Muffaletta Casserole at breakfast or brunch--or even lunch or dinner--and watch it go!

    Here's a tasty vegan spin on New Orleans' Muffaletta Sandwich, a multilayered treat of Italian bread sandwiching deli meat, cheese and a delicious olive spread. This vegan Muffaletta Casserole is just as delicious but it's meat-free and dairy-free, of course, and it's topped with a creamy, cheesy custard. It bakes up wonderfully delicious and golden and crispy in a casserole, and it makes a showstopping dish to serve family or guests. You can easily modify this recipe for a gluten-free, nut-free or low-carb diet.

    An overhead shot of a casserole dish with vegan muffaletta casserole topped with cheese and parsley.

    With Mardi Gras almost here I wanted to share with you another classic New Orleans recipe to add to the many others I already have on the blog, including Vegan Dirty Rice, Vegan Gumbo, Vegan Jambalaya, Vegan Etouffee, and Vegan Fricassee.

    This vegan Muffaletta Casserole is just as tasty and unique as all of those recipes and I hope that like them it also becomes one of your favorites to make and eat year-round.

    Table of Contents
    • What is muffaletta?
    • Can you make a vegan muffaletta?
    • Why you'll love this vegan muffaletta casserole
    • Ingredients
      • For the olive salad:
      • For the creamy custard:
      • Other ingredients for the casserole:
    • How to make the vegan muffaletta casserole
    • Freezing and make-ahead instructions
    • Make a muffaletta sandwich with this recipe
    • More vegan casserole recipes you might enjoy
    • Vegan Muffaletta Casserole
      • For the olive salad
      • For the creamy custard
      • Other ingredients for casserole
      • Make the olive salad
      • Make the creamy vegan custard and prep bread
      • Layer the casserole
      • Bake the casserole

    What is muffaletta?

    Muffaletta, sometimes spelled mufuletta, is a sandwich that originated among Sicilian immigrants in New Orleans. A large Italian sesame seed bun is layered with various kinds of cured meats, including ham and salami, an olive paste and provolone cheese, then cut into pieces and served as individual sandwiches.

    Can you make a vegan muffaletta?

    That's a logical question given that this is a particularly meat-heavy sandwich, with cheese as one of its other key ingredients. However, thanks to the easy availability of vegan deli meats and cheese, you can definitely make a very, very tasty vegan muffaletta--one that even a meat-eater would enjoy.

    And although I will not pretend that this is health food, it has lots of protein, some healthy veggies, and is far better for you than any dish made of cured meats, which come not only with oodles of cholesterol but are also known to be carcinogenic.

    Jay, my 13-year-old son, adores vegan deli meats in sandwiches and this casserole was one I designed as a treat for him. If you have kids or teens of your own, or are cooking for some, you might find that this dish passes their taste test with flying colors.

    Front shot of a piece of vegan muffuletta casserole in a white plate with fork with baking dish in background.

    Why you'll love this vegan muffaletta casserole

    • It's super tasty. There are so many contrasting elements in a muffuletta and together they make each bite an adventure of delicious flavors and textures.
    • It's an easy recipe. There are a couple of elements here you need to pull together, but they come together in a blender or food processor--the olive salad and the creamy, cheesy custard. The only other thing you need to do is layer the casserole and then let the oven do the rest.
    • It's easy to tweak to various diets.
      • Gluten-free or soy-free? Use a gluten-free sandwich bread for the casserole and make sure you buy gluten-free and soy-free deli meats. I used Tofurky slices which do have gluten and soy, but Green Slice and Quorn, among others, make a variety of soy-free, gluten-free, vegan deli meats.
      • Low-carb? Use a low-carb bread--there are so many on the market now and they are quite amazing. I especially love the Old Tyme Italian 647 loaf for this recipe.
      • Nut-free? I used cashew milk in the recipe but if you are nut-free you can use oat milk or soy milk or any other creamy non dairy milk.
    Front top shot of a sandwich from the vegan muffuletta bake.

    Ingredients

    For the olive salad:

    • 1 cup pitted kalamata olives. You can sub with any other green or black olives
    • 2 stalks celery
    • 2 tablespoons parsley
    • 2 roasted bell peppers. Buy jarred or make your own.
    • ยผ medium onion (or a small shallot)
    • 3 cloves garlic
    • 2 level tablespoon capers. These add a nice, sharp tang and saltiness but don't overdo it.
    • 2 tablespoon extra virgin olive oil
    • Salt and ground black pepper to taste

    For the creamy custard:

    • 2 cups non-dairy milk. I used cashew milk but any creamy milk like oat milk or soy milk would be fine here.
    • 2 tablespoons cornstarch. To help thicken the custard.
    • 2 tablespoons nutritional yeast. This adds more cheesiness and flavor.
    • ยฝ teaspoon dried oregano
    • 1 teaspoon onion flakes or onion powder
    • ยฝ teaspoon garlic powder
    • Salt and ground black pepper to taste

    Other ingredients for the casserole:

    • 1 14-oz Italian loaf, cut into 20 slices.
    • 30 vegan deli meat slices. I used a mix of hickory-smoked, oven-roasted and peppered deli slices. Choose any flavors you like. It's good to have a variety so you can get the most flavor in your casserole.
    • 10 slices vegan provolone. I used Violife smoked provolone slices.
    • 4 oz vegan mozzarella shreds. These are optional but they make a nice topping for the casserole and look and taste amazing. If you choose not to use these, drizzle 2 tablespoon of vegan melted butter on the casserole before baking.

    How to make the vegan muffaletta casserole

    • Make the olive salad/tapenade:
      • Place all of the ingredients for the salad in a food processor. Pulse 10 times or until the ingredients are finely chopped. Don't make it a paste. You can chop the ingredients by hand but make sure you chop them as finely as possible.
    Ingredients for olive salad for muffuletta in food processor bowl.
    Chopped ingredients for muffaletta salad in food processor bowl.
    • Make the creamy vegan custard and prep bread:
      • Place all the ingredients for the custard in a blender or a bowl. Blend or whisk until everything is well incorporated. (Expert tip: If whisking by hand, add the cornstarch and other dry ingredients to the bowl first. Drizzle in about a quarter cup of the milk, whisk until everything has mixed and there are no lumps, then add the rest of the milk.)
      • Slice the bread into 20 slices.
    Creamy custard in blender.
    Sliced Italian bread on chopping board.
    • Layer the casserole:
      • Coat the bottom of a four- or five-quart baking dish with olive oil or cooking spray. Layer in half the slices of bread (10 slices). You can either overlap them, as I did, or lay them down flat.
      • Spread the olive salad on the bread. If you overlapped the slices, get in there and make sure you cover the entire slice with the salad. If you have some salad left over reserve it to layer it on later. (I didn't get a photo of the olive salad layered on the bread but if you look at the second photo in the gallery below you will see it peeking out from under the deli slices).
      • Layer on the deli slices. I folded each slice in half and placed it on top of each slice of bread, for a total of three deli slices for every slice of bread.
      • Layer on the cheese. Again, I folded each slice in half and layered it on top of the deli slices.
      • Sprinkle any remaining olive salad over the deli slices.
      • Add a final layer of the remaining 10 slices of bread.
      • Pour the vegan custard over the bread, making sure you soak every slice. It is best to wait at least an hour after this to ensure the custard has soaked into the bread. You can help this process along by placing a similar-sized baking dish on top of the bread to weigh it down.
    First layer of bread in white casserole dish.
    Deli slices layered over the bread in casserole dish.
    Cheese slices and tapenade in baking dish.
    Assembled muffaletta casserole before baking.
    Deli slices, cheese and Italian bread layered in oval white casserole dish.
    Casserole dish with weighted baking dish on top.
    • Bake the casserole:
      • About 15 minutes before you are ready to bake the casserole preheat the oven to 350 degrees Fahrenheit/180 degrees Celsius.
      • Sprinkle the tops of the bread with the vegan mozzarella cheese shreds. Or, if using vegan butter instead of the cheese, melt it and drizzle it over the tops of the bread.
      • Place the casserole in a preheated oven and bake 45 minutes or until the cheese has melted and the bread looks puffy. In the last two minutes of baking turn on the broiler to help the bread turn crispy and the cheese turn golden.
    • Sprinkle the top with more chopped parsley, if you desire. Let the casserole stand 15 minutes before serving.
    Vegan Muffuletta Casserole layered before baking in white oval baking dish.
    Baked vegan muffaletta casserole

    Freezing and make-ahead instructions

    • Store leftovers in the fridge for up to three days in the baking dish wrapped in cling wrap. You can also transfer the casserole to a container and store it.
    • For longer storage, wrap the prepared casserole in freezer-safe wrap and freeze for up to three months. Thaw to room temperature and bake. Leftovers can be frozen in a freezer-safe container, also up to three months.
    • To make this recipe ahead, you can assemble the casserole, cover with cling wrap and refrigerate overnight or up to two days before baking. You can also assemble the casserole, wrap with freezer-safe wrap and freeze. Thaw completely before baking.

    Make a muffaletta sandwich with this recipe

    Not in the mood for a casserole? You can easily turn this recipe into a sandwich--just skip the custard and layer on the sandwiches as you would the casserole. Layer the olive salad over a slice of buttered bread, followed by the deli slices, the cheese, and finally another layer of buttered bread.

    More vegan casserole recipes you might enjoy

    • Vegan Spinach, Sausage and Cheese Casserole
    • Vegan Indian-Spiced Tofu Casserole
    • Vegan French Fry Casserole
    • Vegan Tater Tot Casserole
    • Vegan Hash Brown Casserole
    Overhead partial shot of white oval baking dish with vegan muffaletta casserole.
    Front shot of vegan muffaletta casserole sandwich.

    Vegan Muffaletta Casserole

    This vegan Muffaletta Casserole builds upon the famous New Orleans flavors with vegan deli meats, vegan provolone cheese and a delicious olive salad. All of this goodness is topped with a creamy, cheesy custard. The casserole bakes up wonderfully delicious and golden and crispy, and it makes a showstopping dish to serve family or guests. You can easily modify this recipe for a gluten-free, nut-free or low-carb diet.
    5 from 4 votes
    Print Recipe Pin Recipe Review Recipe
    Course: Breakfast/Brunch/Lunch/Dinner
    Cuisine: American, Louisiana inspired
    Diet: Vegan, Vegetarian
    Keyword: Vegan Muffaletta Casserole
    Prep Time: 20 mins
    Cook Time: 45 mins
    Resting time: 1 hr
    Total Time: 2 hrs 5 mins
    Servings: 10 servings
    Calories: 431kcal
    Author: Vaishali ยท Holy Cow! Vegan Recipes

    Equipment

    • 1 Baking dish (three quarts, approx. Mine is an oval measuring 12 by 9 inches)
    • Food processor
    • Blender (or bowl)

    Ingredients 
    US Customary - Metric

    For the olive salad

    • 1 cup kalamata olives (or any black or green olives, pitted)
    • 2 stalks celery (chopped)
    • 2 tablespoons parsley (chopped)
    • 2 roasted bell peppers (any color. Use jarred or homemade)
    • ยผ medium onion (chopped. Or use 1 small shallot)
    • 3 cloves garlic (chopped)
    • 2 level tablespoons capers
    • 2 tablespoons extra virgin olive oil
    • Salt and ground black pepper to taste

    For the creamy custard

    • 2 cups nondairy milk (I used cashew milk but any creamy milk like oat milk or soy milk is fine)
    • 2 tablespoons cornstarch
    • 2 tablespoons nutritional yeast
    • ยฝ teaspoon dried oregano
    • 1 teaspoon onion flakes (or onion powder)
    • ยฝ teaspoon garlic powder
    • Salt and ground black pepper to taste

    Other ingredients for casserole

    • 14 oz Italian loaf
    • 30 vegan deli meat slices (use an assortment of flavors, if possible. I used a mix of hickory-smoked, oven-roasted and peppered deli slices from Tofurky. If you are soy-free or gluten-free see notes below).
    • 10 slices vegan provolone
    • 4 oz vegan mozzarella shreds
    Prevent your screen from going dark

    Instructions

    Make the olive salad

    • Place all of the ingredients for the salad in a food processor. Pulse 10 times or until the ingredients are finely chopped. Don't make it a paste. You can chop the ingredients by hand but make sure you chop them as finely as possible.

    Make the creamy vegan custard and prep bread

    • Place all the ingredients for the custard in a blender or a bowl. Blend or whisk until everything is well incorporated. (Expert tip:ย If whisking by hand, add the cornstarch and other dry ingredients to the bowl first. Drizzle in about a quarter cup of the milk, whisk until everything has mixed and there are no lumps, then add the rest of the milk.)
    • Cut the bread into 20 slices.

    Layer the casserole

    • Coat the bottom of a four- or five-quart baking dish with olive oil or cooking spray. Layer in half the slices of bread (10 slices). You can either overlap them, as I did, or lay them down flat.
    • Spread the olive salad on the bread. If you overlapped the slices, get in there and make sure you cover the entire slice with the salad. If you have some salad left over reserve it to layer it on later.
    • Layer on the deli slices. I folded each slice in half and placed it on top of each slice of bread, for a total of three deli slices for every slice of bread.
    • Layer on the cheese. Again, I folded each slice in half and layered it on top of the deli slices.
    • Sprinkle any remaining olive salad over the deli slices.
    • Add a final layer of the remaining 10 slices of bread.
    • Pour the vegan custard over the bread, making sure you soak every slice. It is best to wait at least an hour after this to ensure the custard has soaked into the bread. You can help this process along by placing a similar-sized baking dish on top of the bread to weigh it down.

    Bake the casserole

    • About 15 minutes before you are ready to bake the casserole preheat the oven to 350 degrees Fahrenheit/180 degrees Celsius.
    • Sprinkle the tops of the bread with the vegan mozzarella cheese shreds. Or, if using vegan butter instead of the cheese, melt it and drizzle it over the tops of the bread.
    • Place the casserole in a preheated oven and bake 45 minutes or until the cheese has melted and the bread looks puffy. In the last two minutes of baking turn on the broiler to help the bread turn crispy and the cheese turn golden.
    • Sprinkle the top with more chopped parsley, if you desire. Let the casserole stand 15 minutes before serving.

    Recipe notes

    • Gluten-free or soy-free? Use a gluten-free sandwich bread for the casserole and make sure you buy gluten-free and soy-free deli meats. I used Tofurky slices which do have gluten and soy, but Green Slice and Quorn, among others, make a variety of soy-free, gluten-free, vegan deli meats.
    • Low-carb? Use a low-carb bread--there are so many on the market now and they are quite amazing. I especially love the Old Tyme Italian 647 loaf for this recipe.
    • Nut-free? I used cashew milk in the recipe but if you are nut-free you can use oat milk or soy milk or any other creamy non dairy milk.
    • You can easily turn this recipe into a sandwich--just skip the custard and layer on the sandwiches as you would the casserole. Layer the olive salad over a slice of buttered bread, followed by the deli slices, the cheese, and finally another layer of buttered bread.
    • Store casserole leftovers in the fridge for up to three days in the baking dish wrapped in cling wrap. You can also transfer the casserole to a container and refrigerate it.
    • For longer storage, wrap the prepared casserole in freezer-safe wrap and freeze for up to three months. Thaw to room temperature and bake. Leftovers can be frozen in a freezer-safe container, also up to three months.
    • To make this recipe ahead, you can assemble the casserole, cover with cling wrap and refrigerate overnight or up to two days before baking. You can also assemble the casserole, wrap with freezer-safe wrap and freeze. Thaw completely before baking.

    Nutrition

    Calories: 431kcal | Carbohydrates: 33g | Protein: 14g | Fat: 27g | Saturated Fat: 12g | Polyunsaturated Fat: 4g | Monounsaturated Fat: 7g | Trans Fat: 1g | Sodium: 394mg | Potassium: 407mg | Fiber: 3g | Sugar: 15g | Vitamin A: 350IU | Vitamin C: 6mg | Calcium: 95mg | Iron: 2mg
    Tried this recipe?Please leave a comment and recipe rating below!
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    About Vaishali


    Hi! I am so happy you're here. I'm Vaishali, and I've been sharing recipes for delicious vegan food at Holy Cow Vegan since 2007. Every one of the more than 1,000 recipes on this blog has been tried and tested -- and loved -- by my family and I. I hope you will find something here to share with your loved ones. Thanks for stopping by!
    Read more about me here.

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    Comments

    1. Margaret

      March 02, 2022 at 9:16 am

      5 stars
      Made this for Mardi Gras and yummy, so many delicious flavors. We all enjoyed this casserole so much, even the kids couldn't have enough.

      Reply
      • Vaishali

        March 25, 2022 at 1:52 pm

        So happy you loved it!

        Reply

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    Vaishali Honawar, Holy Cow Vegan author, profile photo

    Hi, I'm Vaishali! I cook, eat and share easy, tasty and nutritious plant-based recipes from my Washington, D.C. kitchen, but I never fight a craving for samosas or French fries. 

    More about me โ†’

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    Vaishali Honawar, Holy Cow Vegan author, profile photo

    Hi, I'm Vaishali! I cook, eat and share easy, tasty and nutritious plant-based recipes from my Washington, D.C. kitchen, but I never fight a craving for samosas or French fries. 

    More about me โ†’

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